The BioInsights Podcast

The quest for the Holy Grail in AAV chromatography: empty–full separation

May 25, 2022 Ratish Krishnan & Oliver Rammo Season 1 Episode 3
Show Notes Chapter Markers

Ratish Krishnan and Oliver Rammo share their thoughts on the need for a more nuanced understanding of AAV capture and empty–full separation, and the trends driving innovation in this area.

Q1: What are the challenges in AAV empty–full separation?
Q2: How well understood is empty–full capsid separation in the gene therapy industry? What are some of the misconceptions?
Q3: Olli, how is Merck tackling the AAV capture and empty–full separation challenge?
Q4: How can analytics drive innovation in this area?
Q5: Looking to the future, how do you expect to see technology for AAV capture and empty–full separation evolve over the next 5 years?
Q6: How will future trends in AAV capsid design and production affect purification?