The BioInsights Podcast

Focusing on the fundamentals: what do and don’t we know about mRNA delivery?

March 11, 2024 BioInsights
The BioInsights Podcast
Focusing on the fundamentals: what do and don’t we know about mRNA delivery?
Show Notes Chapter Markers

As excitement around the evolving field of mRNA continues to grow, there remain some
fundamental questions to be answered. David McCall, Senior Editor, Nucleic Acid Insights, spoke with Monash University’s Colin Pouton, Professor of Pharmaceutical Biology and Angus Johnston, Associate Professor, ARC Future Fellow about the key limitations and unknowns of current mRNA delivery approaches, and critical areas for further research and innovation to propel the field forward.

Introduction
Tell us about your background and current work in the nucleic acid delivery space
What for you is the current state of the art in terms of what we can do with mRNA?
What are the key limitations in extending the reach of mRNA technology?
What can and can't we target with mRNA?
What analytical tools and methods do you utilize?
What are some key learnings in terms of monitoring mRNA biodistribution and activity in vivo, and how can these be harnessed?
What do recent findings regarding mRNA delivery tell us about future R&D priorities?
What will be some key areas for future innovation in the mRNA delivery space?
Summing up future goals and priorities