The BioInsights Podcast
The BioInsights Podcast: discussing the challenges of translating novel biologics from bench to clinic to market.
The BioInsights Podcast
Exploring advances in bioconjugation: nanozymes, tissue tropism, and the future of responsive systems
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BioInsights
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Season 4
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Episode 6
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Lauren Coyle (Commissioning Editor, Bioconjugation Insights) speaks to Vincent Rotello (Distinguished Professor of Chemistry, University of Massachusetts Amherst) about the advantages and limitations of different nanomaterial platforms, and emerging strategies such as tissue tropism and responsive nanozymes that could advance targeted therapeutic and diagnostic delivery.
I thought we could start with you telling us a bit about your journey into bioconjugation research. What initially drew you into the field?
While ADCs have captured much of the spotlight, the field extends far beyond these. What other areas of bioconjugation do you see as particularly promising or underappreciated?
What unique advantages do nanomaterials offer as platforms for bioconjugation compared to more traditional approaches?
What are some key challenges in achieving stable, functional conjugation at nanoscale?
Could you provide some examples of how engineered nanomaterial conjugates are being developed for therapeutic or diagnostic applications?
What emerging nanomaterial platforms or conjugation strategies are you most excited about, and have any recent breakthroughs in surface chemistry opened new possibilities for nanomaterial-based conjugates?
Looking ahead, what technological advances or breakthroughs do you think will drive the field forward over the next 5-10 years, and how might this impact research and/or clinical applications?